DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPDST
Uniprot ID:
O14813
Source protein:
Paired mesoderm homeobox protein 2A
Source gene:
PHOX2A
Class:
DEG_SCF_FBW7_1
Location:
184:189
E3 ligase:
FBXW7
DEGRON score:
0.9917
ASA_SCORE:
78.55
COIL:
0.9298
CONS_SCORE:
0.4769
DSS_SCORE:
0.7349
HELIX:
0.0525
FCONS_SCORE:
1.0327
RIG_SCORE:
0.5502
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PHOX2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPDST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14813
Paired mesoderm homeobox protein 2A
DEG_SCF_FBW7_1
184:189
PTPDST
FBXW7
0.9917
More...