DegronMD

Uniprot ID: Q8WW01

Source protein: tRNA-splicing endonuclease subunit Sen15

Source gene: TSEN15

Class: DEG_SCF_FBW7_1

Location: 9:14

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 71.3833

COIL: 0.9417

CONS_SCORE: 0.7967

DSS_SCORE: 0.7619

HELIX: 0.0272

FCONS_SCORE: 1.0513

RIG_SCORE: 0.5957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R22H	TCGA-BS-A0UV	UCEC	TCGA	PTPGCS	DEG_SCF_FBW7_1	0.1111
p.R22H	DO42793	UCEC	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1111
p.G19D	DO229010	COCA	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1944
p.G19D	DO229013	COCA	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1944
p.G19D	DO229016	COCA	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1944
p.G19D	DO229005	COCA	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1944
p.G19D	DO229346	LAML	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1944
p.G19D	DO228941	LICA	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1944
p.G19D	DO230999	LUSC	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1944
p.G19D	DO231043	LUSC	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.1944
p.C13F	DO228952	LICA	ICGC	PTPGCS	DEG_SCF_FBW7_1	0.5996
p.T10I	SIDM00087	Plasma Cell Myeloma	GDSC	PTPGCS	DEG_SCF_FBW7_1	0.8189
p.T10I	ACH-000817	Myeloma	CCLE	PTPGCS	DEG_SCF_FBW7_1	0.8189
p.R4C	ACH-001494	Bile Duct Cancer	CCLE	PTPGCS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WW01	tRNA-splicing endonuclease subunit Sen15	DEG_SCF_FBW7_1	9:14	PTPGCS	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons