DegronMD

Uniprot ID: Q8IVF2

Source protein: Protein AHNAK2

Source gene: AHNAK2

Class: DEG_SCF_FBW7_1

Location: 442:447

E3 ligase: FBXW7

DEGRON score: 0.9654

ASA_SCORE: 69.2167

COIL: 0.9007

CONS_SCORE: 0.3817

DSS_SCORE: 0.8279

HELIX: 0.0428

FCONS_SCORE: 0.9743

RIG_SCORE: 0.5893

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R439W	TCGA-73-4666	LUAD	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.25
p.R439W	DO26230	LUAD	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.R448L	TCGA-D3-A2J6	SKCM	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.3056
p.R448L	TCGA-EE-A3AG	SKCM	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.3056
p.R448L	DO37471	SKCM	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.3056
p.R448L	DO37901	SKCM	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.3056
p.L455M	TCGA-D8-A3Z6	BRCA	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.1111
p.L455M	DO44260	BRCA	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.1111
p.S457N	TCGA-DX-AB32	SARC	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.5
p.S457N	DO220102	SARC	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.5
p.M446R	TCGA-EE-A3JA	SKCM	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.7521
p.M446R	DO47625	SKCM	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.7521
p.E449A	TCGA-EO-A22R	UCEC	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.2778
p.E449A	DO42713	UCEC	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.2778
p.E451K	TCGA-Q1-A5R2	CESC	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.2222
p.E451K	DO49003	CESC	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.2222
p.P444L	TCGA-W3-AA1Q	SKCM	TCGA	PTPGMS	DEG_SCF_FBW7_1	0.7582
p.P444L	DO219487	SKCM	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.7582
p.P446S	DO51938	BLCA	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.6752
p.G454E	DO11854	GBM	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.1389
p.R448Q	DO220851	MELA	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.3056
p.R448Q	SIDM00783	Colorectal Carcinoma	GDSC	PTPGMS	DEG_SCF_FBW7_1	0.3056
p.R448Q	ACH-000971	Colon/Colorectal Cancer	CCLE	PTPGMS	DEG_SCF_FBW7_1	0.3056
p.R448Q	HCT-116	large_intestine	COSMIC	PTPGMS	DEG_SCF_FBW7_1	0.3056
p.R436K	DO220857	MELA	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.1667
p.E453K	DO222702	MELA	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.1667
p.G438S	DO222837	MELA	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.2222
p.P446L	DO232067	ORCA	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.7582
p.P452H	DO37595	SKCM	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.1944
p.G443V	DO42033	UCEC	ICGC	PTPGMS	DEG_SCF_FBW7_1	0.7532
p.T443A	SIDM00643	Non-Cancerous	GDSC	PTPGMS	DEG_SCF_FBW7_1	0.7139
p.T443A	ACH-000327	Lung Cancer	CCLE	PTPGMS	DEG_SCF_FBW7_1	0.7139
p.G450S	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.G450S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.G450S	SIDM01172	Acute Myeloid Leukemia	GDSC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.G450S	SIDM01435	Hepatocellular Carcinoma	GDSC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.G450S	SIDM01451	Pancreatic Carcinoma	GDSC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.G450S	TE-6	oesophagus	COSMIC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.G450S	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.G450S	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGMS	DEG_SCF_FBW7_1	0.25
p.P456S	SW684	soft_tissue	COSMIC	PTPGMS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPGMS

Degron related mutations and impact score

Drug responses associated with AHNAK2 mutations

All proteins holding degron of PTPGMS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF2	Protein AHNAK2	DEG_SCF_FBW7_1	442:447	PTPGMS	FBXW7	0.9654	More...