DegronMD

Uniprot ID: P98088

Source protein: Mucin-5AC

Source gene: MUC5AC

Class: DEG_SCF_FBW7_1

Location: 2065:2070

E3 ligase: FBXW7

DEGRON score: 0.9032

ASA_SCORE: 86.7833

COIL: 0.912

CONS_SCORE: 0.3565

DSS_SCORE: 0.7207

HELIX: 0.0218

FCONS_SCORE: 1.1151

RIG_SCORE: 0.6204

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2064W	SIDM00496	Thyroid Gland Carcinoma	GDSC	PTPHPT	DEG_SCF_FBW7_1	0.3056
p.R2064W	SIDM00157	Neuroblastoma	GDSC	PTPHPT	DEG_SCF_FBW7_1	0.3056
p.R2064W	SIDM01242	Melanoma	GDSC	PTPHPT	DEG_SCF_FBW7_1	0.3056
p.R2064W	SIDM00271	Gastric Carcinoma	GDSC	PTPHPT	DEG_SCF_FBW7_1	0.3056
p.R2064W	SIDM01464	Pancreatic Carcinoma	GDSC	PTPHPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SCF_FBW7_1	2065:2070	PTPHPT	FBXW7	0.9032	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons