DegronMD

Uniprot ID: Q9C0C7

Source protein: Activating molecule in BECN1-regulated autophagy protein 1

Source gene: AMBRA1

Class: DEG_SCF_FBW7_1

Location: 549:554

E3 ligase: FBXW7

DEGRON score: 0.8254

ASA_SCORE: 84.5667

COIL: 0.9195

CONS_SCORE: 0.4398

DSS_SCORE: 0.846

HELIX: 0.0637

FCONS_SCORE: 0.9972

RIG_SCORE: 0.5046

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R554M	TCGA-BG-A222	UCEC	TCGA	PTPHSS	DEG_SCF_FBW7_1	0.8632
p.R554M	DO42977	UCEC	ICGC	PTPHSS	DEG_SCF_FBW7_1	0.8632
p.P550S	TCGA-D1-A0ZZ	UCEC	TCGA	PTPHSS	DEG_SCF_FBW7_1	0.6752
p.P550S	DO43122	UCEC	ICGC	PTPHSS	DEG_SCF_FBW7_1	0.6752
p.P550S	ACH-000786	Lymphoma	CCLE	PTPHSS	DEG_SCF_FBW7_1	0.6752
p.P550S	ACH-000992	Head and Neck Cancer	CCLE	PTPHSS	DEG_SCF_FBW7_1	0.6752
p.E552K	TCGA-E7-A7XN	BLCA	TCGA	PTPHSS	DEG_SCF_FBW7_1	0.7022
p.E552K	DO51878	BLCA	ICGC	PTPHSS	DEG_SCF_FBW7_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SCF_FBW7_1	549:554	PTPHSS	FBXW7	0.8254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons