DegronMD

Uniprot ID: P32780

Source protein: General transcription factor IIH subunit 1

Source gene: GTF2H1

Class: DEG_SCF_FBW7_1

Location: 386:391

E3 ligase: FBXW7

DEGRON score: 0.9791

ASA_SCORE: 81

COIL: 0.8623

CONS_SCORE: 0.2986

DSS_SCORE: 0.3907

HELIX: 0.0983

FCONS_SCORE: 0.9502

RIG_SCORE: 0.7501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S391A	TCGA-AA-3977	COAD	TCGA	PTPIQS	DEG_SCF_FBW7_1	0.7588
p.L381S	DO9082	COAD	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.1944
p.R397W	DO37567	SKCM	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.1667
p.R397W	DO41903	UCEC	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.1667
p.R397W	DO41871	UCEC	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.1667
p.R397W	DO43755	UCEC	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.1667
p.P391Q	DO229216	THCA	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.7035
p.R383Q	DO43306	UCEC	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.25
p.T387M	DO43186	UCEC	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.7423
p.T387M	DO41752	UCEC	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.7423
p.T387M	LoVo	large_intestine	COSMIC	PTPIQS	DEG_SCF_FBW7_1	0.7423
p.L389F	DO41235	UCEC	ICGC	PTPIQS	DEG_SCF_FBW7_1	0.6981
p.L376H	SIDM00901	Endometrial Carcinoma	GDSC	PTPIQS	DEG_SCF_FBW7_1	0.0556
p.L376H	ACH-000940	Endometrial/Uterine Cancer	CCLE	PTPIQS	DEG_SCF_FBW7_1	0.0556
p.L376H	AN3-CA	endometrium	COSMIC	PTPIQS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32780	General transcription factor IIH subunit 1	DEG_SCF_FBW7_1	386:391	PTPIQS	FBXW7	0.9791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons