DegronMD

Uniprot ID: Q86W50

Source protein: RNA N6-adenosine-methyltransferase METTL16

Source gene: METTL16

Class: DEG_SCF_FBW7_1

Location: 411:416

E3 ligase: FBXW7

DEGRON score: 0.6293

ASA_SCORE: 106.4333

COIL: 0.9112

CONS_SCORE: 0.2106

DSS_SCORE: 0.7096

HELIX: 0.0708

FCONS_SCORE: 1.0285

RIG_SCORE: 0.5777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E421V	TCGA-DM-A28H	COAD	TCGA	PTPKES	DEG_SCF_FBW7_1	0.1944
p.D401N	TCGA-DU-6407	LGG	TCGA	PTPKES	DEG_SCF_FBW7_1	0.0556
p.A405T	TCGA-QK-A8ZB	HNSC	TCGA	PTPKES	DEG_SCF_FBW7_1	0.1667
p.S416P	TCGA-W3-AA1V	SKCM	TCGA	PTPKES	DEG_SCF_FBW7_1	0.7863
p.S416P	DO51276	SKCM	ICGC	PTPKES	DEG_SCF_FBW7_1	0.7863
p.P413L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PTPKES	DEG_SCF_FBW7_1	0.7582
p.P413L	ACH-000904	Lung Cancer	CCLE	PTPKES	DEG_SCF_FBW7_1	0.7582
p.P413L	ACH-001362	Lung Cancer	CCLE	PTPKES	DEG_SCF_FBW7_1	0.7582
p.P413L	NCI-H1770	lung	COSMIC	PTPKES	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86W50	RNA N6-adenosine-methyltransferase METTL16	DEG_SCF_FBW7_1	411:416	PTPKES	FBXW7	0.6293	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons