DegronMD

Uniprot ID: Q9UPV0

Source protein: Centrosomal protein of 164 kDa

Source gene: CEP164

Class: DEG_SCF_FBW7_1

Location: 1375:1380

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 75.7833

COIL: 0.834

CONS_SCORE: 0.7111

DSS_SCORE: 0.3648

HELIX: 0.1132

FCONS_SCORE: 1.0122

RIG_SCORE: 0.7135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1375H	TCGA-A5-A0G2	UCEC	TCGA	PTPLES	DEG_SCF_FBW7_1	0.7694
p.P1375H	DO41235	UCEC	ICGC	PTPLES	DEG_SCF_FBW7_1	0.7694
p.P1369Q	TCGA-BQ-7053	KIRP	TCGA	PTPLES	DEG_SCF_FBW7_1	0.1667
p.P1369Q	DO20946	KIRP	ICGC	PTPLES	DEG_SCF_FBW7_1	0.1667
p.L1371R	DO233840	GACA	ICGC	PTPLES	DEG_SCF_FBW7_1	0.2222
p.E1379D	DO229018	LICA	ICGC	PTPLES	DEG_SCF_FBW7_1	0.5647
p.R1381S	DO229026	LICA	ICGC	PTPLES	DEG_SCF_FBW7_1	0.3056
p.I1368T	SIDM00173	Head and Neck Carcinoma	GDSC	PTPLES	DEG_SCF_FBW7_1	0.1389
p.I1368T	HCC-56	large_intestine	COSMIC	PTPLES	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SCF_FBW7_1	1375:1380	PTPLES	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons