DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPLTE
Uniprot ID:
Q8NBZ9
Source protein:
Putative uncharacterized protein NEXN-AS1
Source gene:
NEXN-AS1
Class:
DEG_SCF_FBW7_2
Location:
59:64
E3 ligase:
FBXW7
DEGRON score:
0.9173
ASA_SCORE:
74.4
COIL:
0.7717
CONS_SCORE:
0
DSS_SCORE:
0.7154
HELIX:
0.0228
FCONS_SCORE:
0
RIG_SCORE:
0.6231
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NEXN-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPLTE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NBZ9
Putative uncharacterized protein NEXN-AS1
DEG_SCF_FBW7_2
59:64
PTPLTE
FBXW7
0.9173
More...