DegronMD

Uniprot ID: Q8NFL0

Source protein: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

Source gene: B3GNT7

Class: DEG_SCF_FBW7_1

Location: 71:76

E3 ligase: FBXW7

DEGRON score: 0.753

ASA_SCORE: 78.3333

COIL: 0.8672

CONS_SCORE: 0.3884

DSS_SCORE: 0.6033

HELIX: 0.0702

FCONS_SCORE: 0.9337

RIG_SCORE: 0.6648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T72M	TCGA-06-0137	GBM	TCGA	PTPMAS	DEG_SCF_FBW7_1	0.7423
p.T72M	TCGA-A6-5661	COAD	TCGA	PTPMAS	DEG_SCF_FBW7_1	0.7423
p.T72M	TCGA-B5-A1MX	UCEC	TCGA	PTPMAS	DEG_SCF_FBW7_1	0.7423
p.T72M	DO8634	COAD	ICGC	PTPMAS	DEG_SCF_FBW7_1	0.7423
p.T72M	DO227996	COCA	ICGC	PTPMAS	DEG_SCF_FBW7_1	0.7423
p.T72M	DO41999	UCEC	ICGC	PTPMAS	DEG_SCF_FBW7_1	0.7423
p.A70S	TCGA-AR-A1AV	BRCA	TCGA	PTPMAS	DEG_SCF_FBW7_1	0.3056
p.A70S	TCGA-CR-6471	HNSC	TCGA	PTPMAS	DEG_SCF_FBW7_1	0.3056
p.A70S	DO4659	BRCA	ICGC	PTPMAS	DEG_SCF_FBW7_1	0.3056
p.A70S	DO15166	HNSC	ICGC	PTPMAS	DEG_SCF_FBW7_1	0.3056
p.S76Y	DO222525	BTCA	ICGC	PTPMAS	DEG_SCF_FBW7_1	0.712
p.P73L	SIDM00617	Hepatocellular Carcinoma	GDSC	PTPMAS	DEG_SCF_FBW7_1	0.7582
p.P73L	JHH-2	liver	COSMIC	PTPMAS	DEG_SCF_FBW7_1	0.7582
p.P65L	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PTPMAS	DEG_SCF_FBW7_1	0.1667
p.P65L	ACH-000869	Lung Cancer	CCLE	PTPMAS	DEG_SCF_FBW7_1	0.1667
p.P65L	NCI-H1568	lung	COSMIC	PTPMAS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFL0	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	DEG_SCF_FBW7_1	71:76	PTPMAS	FBXW7	0.753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons