DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PTPRRT
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SCF_FBW7_1
Location:
2744:2749
E3 ligase:
FBXW7
DEGRON score:
0.8933
ASA_SCORE:
112.2167
COIL:
0.929
CONS_SCORE:
0.3101
DSS_SCORE:
0.6881
HELIX:
0.0203
FCONS_SCORE:
0.9993
RIG_SCORE:
0.6502
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T2741I
SIDM00516
Melanoma
GDSC
PTPRRT
DEG_SCF_FBW7_1
0.25
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPRRT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P98088
Mucin-5AC
DEG_SCF_FBW7_1
2744:2749
PTPRRT
FBXW7
0.8933
More...