DegronMD

Uniprot ID: Q8NBR0

Source protein: Tumor protein p53-inducible protein 13

Source gene: TP53I13

Class: DEG_SCF_FBW7_2

Location: 303:308

E3 ligase: FBXW7

DEGRON score: 0.93

ASA_SCORE: 74.6333

COIL: 0.7945

CONS_SCORE: 0.694

DSS_SCORE: 0.4867

HELIX: 0.1813

FCONS_SCORE: 1.1993

RIG_SCORE: 0.6941

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R306H	TCGA-2W-A8YY	CESC	TCGA	PTPRTE	DEG_SCF_FBW7_2	0.7133
p.R306H	TCGA-AD-5900	COAD	TCGA	PTPRTE	DEG_SCF_FBW7_2	0.7133
p.R306H	TCGA-EI-6882	READ	TCGA	PTPRTE	DEG_SCF_FBW7_2	0.7133
p.R306H	TCGA-WS-AB45	COAD	TCGA	PTPRTE	DEG_SCF_FBW7_2	0.7133
p.R306H	DO223732	CESC	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.7133
p.R306H	DO51734	COAD	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.7133
p.R306H	DO8514	COAD	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.7133
p.R306H	DO36531	READ	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.7133
p.A311V	TCGA-AA-A022	COAD	TCGA	PTPRTE	DEG_SCF_FBW7_2	0.25
p.A311V	DO10647	COAD	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.25
p.R298W	TCGA-BR-4362	STAD	TCGA	PTPRTE	DEG_SCF_FBW7_2	0.1944
p.R298W	DO234462	ESAD	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.1944
p.R298W	DO38336	STAD	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.1944
p.R306C	TCGA-CG-4306	STAD	TCGA	PTPRTE	DEG_SCF_FBW7_2	0.719
p.R306C	DO38567	STAD	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.719
p.P296H	DO228935	COCA	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.1389
p.A314V	DO222769	COCA	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.1667
p.A314S	DO231986	LICA	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.1667
p.M315I	DO50721	ORCA	ICGC	PTPRTE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBR0	Tumor protein p53-inducible protein 13	DEG_SCF_FBW7_2	303:308	PTPRTE	FBXW7	0.93	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons