DegronMD

Uniprot ID: P55265

Source protein: Double-stranded RNA-specific adenosine deaminase

Source gene: ADAR

Class: DEG_SCF_FBW7_1

Location: 602:607

E3 ligase: FBXW7

DEGRON score: 0.9877

ASA_SCORE: 70.6167

COIL: 0.8468

CONS_SCORE: 0.3309

DSS_SCORE: 0.5774

HELIX: 0.1165

FCONS_SCORE: 0.9539

RIG_SCORE: 0.6365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q600H	TCGA-50-5933	LUAD	TCGA	PTPSAT	DEG_SCF_FBW7_1	0.2778
p.Q600R	TCGA-AX-A2HD	UCEC	TCGA	PTPSAT	DEG_SCF_FBW7_1	0.2778
p.V616I	TCGA-CG-5727	STAD	TCGA	PTPSAT	DEG_SCF_FBW7_1	0.0833
p.V616I	TCGA-FI-A2D5	UCEC	TCGA	PTPSAT	DEG_SCF_FBW7_1	0.0833
p.G612V	TCGA-D3-A3CE	SKCM	TCGA	PTPSAT	DEG_SCF_FBW7_1	0.1944
p.K613N	TCGA-SY-A9G5	BLCA	TCGA	PTPSAT	DEG_SCF_FBW7_1	0.6111
p.A608D	DO229019	LICA	ICGC	PTPSAT	DEG_SCF_FBW7_1	0.75
p.A608V	DO42280	UCEC	ICGC	PTPSAT	DEG_SCF_FBW7_1	0.75
p.E594D	SIDM00920	Breast Carcinoma	GDSC	PTPSAT	DEG_SCF_FBW7_1	0.1111
p.E594D	ACH-000783	Breast Cancer	CCLE	PTPSAT	DEG_SCF_FBW7_1	0.1111
p.E594D	CAMA-1	breast	COSMIC	PTPSAT	DEG_SCF_FBW7_1	0.1111
p.S603F	HCT-15	large_intestine	COSMIC	PTPSAT	DEG_SCF_FBW7_1	0.7982
p.S603C	SW684	soft_tissue	COSMIC	PTPSAT	DEG_SCF_FBW7_1	0.7541
p.D602N	HCC-366	lung	COSMIC	PTPSAT	DEG_SCF_FBW7_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55265	Double-stranded RNA-specific adenosine deaminase	DEG_SCF_FBW7_1	602:607	PTPSAT	FBXW7	0.9877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons