DegronMD

Uniprot ID: Q6N043

Source protein: Zinc finger protein 280D

Source gene: ZNF280D

Class: DEG_SCF_FBW7_1

Location: 531:536

E3 ligase: FBXW7

DEGRON score: 0.9158

ASA_SCORE: 85.9333

COIL: 0.8903

CONS_SCORE: 0.2718

DSS_SCORE: 0.5927

HELIX: 0.0552

FCONS_SCORE: 0.6868

RIG_SCORE: 0.6251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P544T	DO48413	BLCA	ICGC	PTPSIS	DEG_SCF_FBW7_1	0.1111
p.A541D	DO222884	COCA	ICGC	PTPSIS	DEG_SCF_FBW7_1	0.1944
p.A545T	DO50791	LIRI	ICGC	PTPSIS	DEG_SCF_FBW7_1	0.5278
p.P533L	SIDM00849	Kidney Carcinoma	GDSC	PTPSIS	DEG_SCF_FBW7_1	0.7582
p.V522I	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PTPSIS	DEG_SCF_FBW7_1	0.0833
p.V522I	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSIS	DEG_SCF_FBW7_1	0.0833
p.R535M	ACH-000945	Lung Cancer	CCLE	PTPSIS	DEG_SCF_FBW7_1	0.8632
p.R535M	NCI-H650	lung	COSMIC	PTPSIS	DEG_SCF_FBW7_1	0.8632

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6N043	Zinc finger protein 280D	DEG_SCF_FBW7_1	531:536	PTPSIS	FBXW7	0.9158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons