DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPSLT
Uniprot ID:
Q96FF7
Source protein:
Uncharacterized protein MISP3
Source gene:
MISP3
Class:
DEG_SCF_FBW7_1
Location:
184:189
E3 ligase:
FBXW7
DEGRON score:
0.9886
ASA_SCORE:
73.1667
COIL:
0.8903
CONS_SCORE:
0.6106
DSS_SCORE:
0.5644
HELIX:
0.0615
FCONS_SCORE:
0.9334
RIG_SCORE:
0.6937
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MISP3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPSLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96FF7
Uncharacterized protein MISP3
DEG_SCF_FBW7_1
184:189
PTPSLT
FBXW7
0.9886
More...