DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPTAS
Uniprot ID:
Q7L0X0
Source protein:
TLR4 interactor with leucine rich repeats
Source gene:
TRIL
Class:
DEG_SCF_FBW7_1
Location:
530:535
E3 ligase:
FBXW7
DEGRON score:
0.8646
ASA_SCORE:
66.5167
COIL:
0.8677
CONS_SCORE:
0.3104
DSS_SCORE:
0.8495
HELIX:
0.0177
FCONS_SCORE:
1.0164
RIG_SCORE:
0.5556
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A543T
SIDM00333
Endometrial Carcinoma
GDSC
PTPTAS
DEG_SCF_FBW7_1
0.1111
p.A539E
SIDM00576
Acute Myeloid Leukemia
GDSC
PTPTAS
DEG_SCF_FBW7_1
0.2222
Drug responses associated with TRIL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPTAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7L0X0
TLR4 interactor with leucine rich repeats
DEG_SCF_FBW7_1
530:535
PTPTAS
FBXW7
0.8646
More...