DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: DEG_SCF_FBW7_1

Location: 2302:2307

E3 ligase: FBXW7

DEGRON score: 0.8781

ASA_SCORE: 100.2667

COIL: 0.9572

CONS_SCORE: 0.5459

DSS_SCORE: 0.8296

HELIX: 0.0092

FCONS_SCORE: 1.0183

RIG_SCORE: 0.5334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2299S	DO233737	GACA	ICGC	PTPTHS	DEG_SCF_FBW7_1	0.25
p.R2317W	DO222749	MELA	ICGC	PTPTHS	DEG_SCF_FBW7_1	0.0556
p.R2317W	DO33200	PACA	ICGC	PTPTHS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1R4	Transcription factor HIVEP3	DEG_SCF_FBW7_1	2302:2307	PTPTHS	FBXW7	0.8781	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons