DegronMD

Uniprot ID: P49450

Source protein: Histone H3-like centromeric protein A

Source gene: CENPA

Class: DEG_SCF_FBW7_1

Location: 20:27

E3 ligase: FBXW7

DEGRON score: 0.9752

ASA_SCORE: 88.6

COIL: 0.9616

CONS_SCORE: 0.5428

DSS_SCORE: 0.9167

HELIX: 0.0144

FCONS_SCORE: 1.0499

RIG_SCORE: 0.4366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S36F	TCGA-A5-A0G2	UCEC	TCGA	PTPTPGPS	DEG_SCF_FBW7_1	0.0833
p.S36F	DO41235	UCEC	ICGC	PTPTPGPS	DEG_SCF_FBW7_1	0.0833
p.A35T	TCGA-AZ-4315	COAD	TCGA	PTPTPGPS	DEG_SCF_FBW7_1	0.1111
p.A35T	DO8842	COAD	ICGC	PTPTPGPS	DEG_SCF_FBW7_1	0.1111
p.S19T	ACH-000956	Prostate Cancer	CCLE	PTPTPGPS	DEG_SCF_FBW7_1	0.75
p.P13Q	ACH-000980	Lung Cancer	CCLE	PTPTPGPS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49450	Histone H3-like centromeric protein A	DEG_SCF_FBW7_1	20:27	PTPTPGPS	FBXW7	0.9752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons