DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPTPGQS
Uniprot ID:
Q6NT89
Source protein:
TMF-regulated nuclear protein 1
Source gene:
TRNP1
Class:
DEG_SCF_FBW7_1
Location:
44:51
E3 ligase:
FBXW7
DEGRON score:
0.9119
ASA_SCORE:
90.1125
COIL:
0.9736
CONS_SCORE:
0.592
DSS_SCORE:
0.8984
HELIX:
0.0101
FCONS_SCORE:
0.9881
RIG_SCORE:
0.4996
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P44S
SIDM01298
Esophageal Carcinoma
GDSC
PTPTPGQS
DEG_SCF_FBW7_1
0.6752
Drug responses associated with TRNP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPTPGQS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6NT89
TMF-regulated nuclear protein 1
DEG_SCF_FBW7_1
44:51
PTPTPGQS
FBXW7
0.9119
More...