DegronMD

Uniprot ID: P57789

Source protein: Potassium channel subfamily K member 10

Source gene: KCNK10

Class: DEG_SCF_FBW7_1

Location: 37:44

E3 ligase: FBXW7

DEGRON score: 0.9776

ASA_SCORE: 89.875

COIL: 0.9428

CONS_SCORE: 0.329

DSS_SCORE: 0.6517

HELIX: 0.0276

FCONS_SCORE: 1.598

RIG_SCORE: 0.6482

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P40R	TCGA-05-4427	LUAD	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.7512
p.S31R	TCGA-21-1070	LUSC	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.1667
p.S52F	TCGA-21-1079	LUSC	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.1111
p.S52F	SIDM01066	Melanoma	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.1111
p.S52F	IGR-37	skin	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.1111
p.N34Y	TCGA-95-7039	LUAD	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.25
p.Q28L	TCGA-99-8025	LUAD	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.0833
p.P38L	TCGA-CD-8529	STAD	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.P38L	TCGA-FS-A1ZA	SKCM	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.P38L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.P38L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.P38S	TCGA-D3-A8GB	SKCM	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.6752
p.S51F	TCGA-DX-AB2E	SARC	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.1389
p.S51F	TCGA-IH-A3EA	SKCM	TCGA	PTPTPRLS	DEG_SCF_FBW7_1	0.1389
p.P37L	DO222973	BTCA	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.6471
p.P37L	DO48246	ESCA	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.6471
p.P37L	ACH-000966	Ovarian Cancer	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.6471
p.P37L	IGROV-1	ovary	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.6471
p.P41L	DO222555	ESCA	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.P41L	ACH-000476	Liver Cancer	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.P41L	JHH-4	liver	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.T40N	DO229015	LICA	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.7055
p.V51E	DO26394	LUAD	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.1389
p.N29Y	DO23907	LUAD	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.1111
p.P35R	DO23666	LUAD	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.2778
p.A34P	DO231152	LUSC	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.25
p.S47F	DO26846	LUSC	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.25
p.S47F	ACH-000650	Skin Cancer	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.25
p.S47F	IGR-37	skin	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.25
p.S46F	DO220073	SARC	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.2778
p.S46F	DO37667	SKCM	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.2778
p.P37S	DO229456	SKCA	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.6752
p.P37S	SIDM01145	Gastric Carcinoma	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.6752
p.P37S	NCI-SNU-16	stomach	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.6752
p.P33L	DO37551	SKCM	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.P33L	DO47753	STAD	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.P33L	ACH-001737	Leukemia	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.P33L	ACH-002222	Leukemia	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.P33L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.P33S	DO50280	SKCM	ICGC	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.A32T	SIDM01943	Colorectal Carcinoma	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.1944
p.R53Q	SIDM01175	Other Sarcomas	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.0833
p.R53Q	SW684	soft_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.0833
p.P42T	SIDM00417	Plasma Cell Myeloma	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P42T	SIDM00927	Small Cell Lung Carcinoma	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P42T	NCI-H510A	lung	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P42T	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P42L	SIDM00151	Ovarian Carcinoma	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.P42L	IGROV-1	ovary	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7582
p.R47H	SIDM00566	Oral Cavity Carcinoma	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.25
p.R47H	SIDM00220	Ovarian Carcinoma	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.25
p.R47H	OC-314	ovary	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.25
p.P38T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P38T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P32S	ACH-000581	Gastric Cancer	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.1944
p.P32S	NCI-SNU-16	stomach	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.1944
p.P37T	ACH-000626	Myeloma	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P37T	ACH-000871	Lung Cancer	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P37T	NCI-H510A	lung	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.P37T	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031
p.R42H	ACH-000962	Ovarian Cancer	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.7133
p.R42H	ACH-001145	Ovarian Cancer	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.7133
p.R42H	OC-314	ovary	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7133
p.P33T	ACH-001127	Leukemia	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.P33T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.R48Q	ACH-002309	Sarcoma	CCLE	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.R48Q	SW684	soft_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.2222
p.P46L	JHH-4	liver	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.2778
p.T45P	CW-2	large_intestine	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.3056
p.V52A	SW684	soft_tissue	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.1111
p.T40P	CW-2	large_intestine	COSMIC	PTPTPRLS	DEG_SCF_FBW7_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPTPRLS

Degron related mutations and impact score

Drug responses associated with KCNK10 mutations

All proteins holding degron of PTPTPRLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57789	Potassium channel subfamily K member 10	DEG_SCF_FBW7_1	37:44	PTPTPRLS	FBXW7	0.9776	More...