DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPTPSST
Uniprot ID:
Q96MY1
Source protein:
Nucleolar protein 4-like
Source gene:
NOL4L
Class:
DEG_SCF_FBW7_1
Location:
381:388
E3 ligase:
FBXW7
DEGRON score:
0.8587
ASA_SCORE:
91.9125
COIL:
0.9618
CONS_SCORE:
0.3762
DSS_SCORE:
0.7599
HELIX:
0.0239
FCONS_SCORE:
0.9327
RIG_SCORE:
0.5585
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NOL4L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPTPSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96MY1
Nucleolar protein 4-like
DEG_SCF_FBW7_1
381:388
PTPTPSST
FBXW7
0.8587
More...