DegronMD

Uniprot ID: P98164

Source protein: Low-density lipoprotein receptor-related protein 2

Source gene: LRP2

Class: DEG_SCF_FBW7_1

Location: 4631:4636

E3 ligase: FBXW7

DEGRON score: 0.9379

ASA_SCORE: 84.9167

COIL: 0.93

CONS_SCORE: 0.3753

DSS_SCORE: 0.7448

HELIX: 0.031

FCONS_SCORE: 0.9093

RIG_SCORE: 0.6048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4646T	TCGA-66-2755	LUSC	TCGA	PTPTYS	DEG_SCF_FBW7_1	0.0556
p.A4646T	DO27365	LUSC	ICGC	PTPTYS	DEG_SCF_FBW7_1	0.0556
p.R4629T	TCGA-85-8048	LUSC	TCGA	PTPTYS	DEG_SCF_FBW7_1	0.2778
p.R4629T	DO27389	LUSC	ICGC	PTPTYS	DEG_SCF_FBW7_1	0.2778
p.S4627L	TCGA-EO-A22X	UCEC	TCGA	PTPTYS	DEG_SCF_FBW7_1	0.6667
p.S4627L	TCGA-FR-A726	SKCM	TCGA	PTPTYS	DEG_SCF_FBW7_1	0.6667
p.S4627L	TCGA-VR-A8EO	ESCA	TCGA	PTPTYS	DEG_SCF_FBW7_1	0.6667
p.S4627L	DO48665	SKCM	ICGC	PTPTYS	DEG_SCF_FBW7_1	0.6667
p.S4627L	DO43907	UCEC	ICGC	PTPTYS	DEG_SCF_FBW7_1	0.6667
p.P4625L	DO220886	MELA	ICGC	PTPTYS	DEG_SCF_FBW7_1	0.1667
p.P4633L	DO27943	ORCA	ICGC	PTPTYS	DEG_SCF_FBW7_1	0.7582
p.T4641S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PTPTYS	DEG_SCF_FBW7_1	0.6389
p.T4641S	SIDM00954	Breast Carcinoma	GDSC	PTPTYS	DEG_SCF_FBW7_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98164	Low-density lipoprotein receptor-related protein 2	DEG_SCF_FBW7_1	4631:4636	PTPTYS	FBXW7	0.9379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons