DegronMD

Uniprot ID: Q5VWQ8

Source protein: Disabled homolog 2-interacting protein

Source gene: DAB2IP

Class: DEG_SCF_FBW7_1

Location: 807:813

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 78.7571

COIL: 0.9349

CONS_SCORE: 0.3184

DSS_SCORE: 0.7605

HELIX: 0.0204

FCONS_SCORE: 0.9857

RIG_SCORE: 0.6002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A808V	TCGA-A5-A1OF	UCEC	TCGA	PTTPGTS	DEG_SCF_FBW7_1	0.6936
p.A808V	DO42568	UCEC	ICGC	PTTPGTS	DEG_SCF_FBW7_1	0.6936
p.D820N	TCGA-AP-A1DV	UCEC	TCGA	PTTPGTS	DEG_SCF_FBW7_1	0.1389
p.D820N	DO43186	UCEC	ICGC	PTTPGTS	DEG_SCF_FBW7_1	0.1389
p.S799C	TCGA-CC-A3M9	LIHC	TCGA	PTTPGTS	DEG_SCF_FBW7_1	0.5556
p.S799C	DO44946	LIHC	ICGC	PTTPGTS	DEG_SCF_FBW7_1	0.5556
p.Q806H	TCGA-D6-A6ES	HNSC	TCGA	PTTPGTS	DEG_SCF_FBW7_1	0.3056
p.Q806H	DO52086	HNSC	ICGC	PTTPGTS	DEG_SCF_FBW7_1	0.3056
p.P797Q	TCGA-DA-A1IA	SKCM	TCGA	PTTPGTS	DEG_SCF_FBW7_1	0.0556
p.P797Q	DO38022	SKCM	ICGC	PTTPGTS	DEG_SCF_FBW7_1	0.0556
p.S799A	TCGA-G3-A5SJ	LIHC	TCGA	PTTPGTS	DEG_SCF_FBW7_1	0.5556
p.S799A	DO44938	LIHC	ICGC	PTTPGTS	DEG_SCF_FBW7_1	0.5556
p.R816C	TCGA-XF-AAN7	BLCA	TCGA	PTTPGTS	DEG_SCF_FBW7_1	0.25
p.R816C	DO51946	BLCA	ICGC	PTTPGTS	DEG_SCF_FBW7_1	0.25
p.P815S	DO228349	MALY	ICGC	PTTPGTS	DEG_SCF_FBW7_1	0.2778
p.G817V	SIDM01146	Gastric Carcinoma	GDSC	PTTPGTS	DEG_SCF_FBW7_1	0.2222
p.G817V	NCI-SNU-1	stomach	COSMIC	PTTPGTS	DEG_SCF_FBW7_1	0.2222
p.S814L	SIDM00560	Gastric Carcinoma	GDSC	PTTPGTS	DEG_SCF_FBW7_1	0.3056
p.A806V	ACH-000887	Brain Cancer	CCLE	PTTPGTS	DEG_SCF_FBW7_1	0.3056
p.R823I	ACH-001498	Lymphoma	CCLE	PTTPGTS	DEG_SCF_FBW7_1	0.0556
p.R819W	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPGTS	DEG_SCF_FBW7_1	0.1667
p.A816V	NB5	autonomic_ganglia	COSMIC	PTTPGTS	DEG_SCF_FBW7_1	0.25
p.A816V	CAL-54	kidney	COSMIC	PTTPGTS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWQ8	Disabled homolog 2-interacting protein	DEG_SCF_FBW7_1	807:813	PTTPGTS	FBXW7	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons