DegronMD

Uniprot ID: Q4ZHG4

Source protein: Fibronectin type III domain-containing protein 1

Source gene: FNDC1

Class: DEG_SCF_FBW7_1

Location: 1505:1511

E3 ligase: FBXW7

DEGRON score: 0.9684

ASA_SCORE: 90.7143

COIL: 0.9676

CONS_SCORE: 0.7625

DSS_SCORE: 0.7405

HELIX: 0.011

FCONS_SCORE: 1.0462

RIG_SCORE: 0.7026

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1519Q	TCGA-AX-A1CE	UCEC	TCGA	PTTPIPT	DEG_SCF_FBW7_1	0.1111
p.H1520Y	TCGA-CZ-5456	KIRC	TCGA	PTTPIPT	DEG_SCF_FBW7_1	0.0833
p.D1521N	TCGA-F5-6814	READ	TCGA	PTTPIPT	DEG_SCF_FBW7_1	0.0556
p.R1496W	TCGA-G4-6293	COAD	TCGA	PTTPIPT	DEG_SCF_FBW7_1	0.0833
p.R1496W	SIDM00613	Glioblastoma	GDSC	PTTPIPT	DEG_SCF_FBW7_1	0.0833
p.V1496D	DO227470	BRCA	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.0833
p.T1511A	DO228483	BRCA	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.7139
p.T1511A	DO229010	COCA	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.7139
p.T1511A	DO229016	COCA	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.7139
p.T1511A	DO229003	COCA	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.7139
p.T1511A	DO229505	LAML	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.7139
p.T1511A	DO228947	LICA	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.7139
p.V1496I	DO227858	PBCA	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.0833
p.V1496I	DO51761	STAD	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.0833
p.V1496I	DO42113	UCEC	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.0833
p.V1496I	DO41199	UCEC	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.0833
p.P1510S	DO38069	SKCM	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.5641
p.S1516L	DO41919	UCEC	ICGC	PTTPIPT	DEG_SCF_FBW7_1	0.1944
p.T1516N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PTTPIPT	DEG_SCF_FBW7_1	0.1944
p.T1516N	SIDM01240	Melanoma	GDSC	PTTPIPT	DEG_SCF_FBW7_1	0.1944
p.T1516N	SIDM00676	Bladder Carcinoma	GDSC	PTTPIPT	DEG_SCF_FBW7_1	0.1944
p.T1516N	SIDM01000	Melanoma	GDSC	PTTPIPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SCF_FBW7_1	1505:1511	PTTPIPT	FBXW7	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons