DegronMD

Uniprot ID: P24928

Source protein: DNA-directed RNA polymerase II subunit RPB1

Source gene: POLR2A

Class: DEG_SCF_FBW7_1

Location: 1883:1889

E3 ligase: FBXW7

DEGRON score: 0.9374

ASA_SCORE: 83.1286

COIL: 0.947

CONS_SCORE: 0.2436

DSS_SCORE: 0.5213

HELIX: 0.0156

FCONS_SCORE: -0.0009

RIG_SCORE: 0.5966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1875L	TCGA-AP-A059	UCEC	TCGA	PTTPKYS	DEG_SCF_FBW7_1	0.5556
p.S1875L	DO41361	UCEC	ICGC	PTTPKYS	DEG_SCF_FBW7_1	0.5556
p.Y1874H	TCGA-CG-5721	STAD	TCGA	PTTPKYS	DEG_SCF_FBW7_1	0.5278
p.Y1874H	DO38192	STAD	ICGC	PTTPKYS	DEG_SCF_FBW7_1	0.5278
p.T1898A	TCGA-CK-5912	COAD	TCGA	PTTPKYS	DEG_SCF_FBW7_1	0.5278
p.T1898A	DO10204	COAD	ICGC	PTTPKYS	DEG_SCF_FBW7_1	0.5278
p.K1887N	TCGA-EO-A22U	UCEC	TCGA	PTTPKYS	DEG_SCF_FBW7_1	0.5806
p.K1887N	DO43755	UCEC	ICGC	PTTPKYS	DEG_SCF_FBW7_1	0.5806
p.S1896F	TCGA-IH-A3EA	SKCM	TCGA	PTTPKYS	DEG_SCF_FBW7_1	0.5833
p.S1896F	DO37667	SKCM	ICGC	PTTPKYS	DEG_SCF_FBW7_1	0.5833
p.P1890S	DO231858	LINC	ICGC	PTTPKYS	DEG_SCF_FBW7_1	0.3056
p.T1894S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTTPKYS	DEG_SCF_FBW7_1	0.6389
p.T1894S	ACH-000981	Leukemia	CCLE	PTTPKYS	DEG_SCF_FBW7_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24928	DNA-directed RNA polymerase II subunit RPB1	DEG_SCF_FBW7_1	1883:1889	PTTPKYS	FBXW7	0.9374	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons