DegronMD

Uniprot ID: Q8WV28

Source protein: B-cell linker protein

Source gene: BLNK

Class: DEG_SCF_FBW7_1

Location: 252:258

E3 ligase: FBXW7

DEGRON score: 0.9594

ASA_SCORE: 99.4143

COIL: 0.96

CONS_SCORE: 0.3925

DSS_SCORE: 0.7388

HELIX: 0.0149

FCONS_SCORE: 0.892

RIG_SCORE: 0.626

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q265H	TCGA-19-5956	GBM	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.1389
p.Q265H	DO13863	GBM	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.1389
p.S243C	TCGA-21-1081	LUSC	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.5278
p.S243C	DO26930	LUSC	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.5278
p.T253M	TCGA-A5-A1OF	UCEC	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.7423
p.T253M	TCGA-AX-A1CE	UCEC	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.7423
p.T253M	TCGA-FI-A2D0	UCEC	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.7423
p.T253M	TCGA-LN-A49N	ESCA	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.7423
p.T253M	DO42280	UCEC	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.7423
p.T253M	DO42568	UCEC	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.7423
p.T253M	DO43891	UCEC	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.7423
p.P244L	TCGA-CG-4305	STAD	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.1111
p.P244L	TCGA-L5-A4OI	ESCA	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.1111
p.P244L	DO38823	STAD	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.1111
p.P244L	SIDM02013	Colorectal Carcinoma	GDSC	PTTPLKT	DEG_SCF_FBW7_1	0.1111
p.V261I	TCGA-VQ-A91K	STAD	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.25
p.V261I	DO51785	STAD	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.25
p.R247Q	TCGA-YD-A9TA	SKCM	TCGA	PTTPLKT	DEG_SCF_FBW7_1	0.1944
p.R247Q	DO219503	SKCM	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.1944
p.R247Q	SIDM02049	Pancreatic Carcinoma	GDSC	PTTPLKT	DEG_SCF_FBW7_1	0.1944
p.P242Q	DO229027	LICA	ICGC	PTTPLKT	DEG_SCF_FBW7_1	0.0556
p.A262V	SIDM02015	Colorectal Carcinoma	GDSC	PTTPLKT	DEG_SCF_FBW7_1	0.2222
p.A267D	ACH-000634	Brain Cancer	CCLE	PTTPLKT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WV28	B-cell linker protein	DEG_SCF_FBW7_1	252:258	PTTPLKT	FBXW7	0.9594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons