DegronMD

Uniprot ID: P26367

Source protein: Paired box protein Pax-6

Source gene: PAX6

Class: DEG_SCF_FBW7_1

Location: 302:308

E3 ligase: FBXW7

DEGRON score: 0.9531

ASA_SCORE: 56.5571

COIL: 0.9101

CONS_SCORE: 0.4432

DSS_SCORE: 0.5202

HELIX: 0.0376

FCONS_SCORE: 0.9911

RIG_SCORE: 0.6906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P296H	TCGA-39-5040	LUSC	TCGA	PTTPVSS	DEG_SCF_FBW7_1	0.1667
p.T317I	TCGA-69-7979	LUAD	TCGA	PTTPVSS	DEG_SCF_FBW7_1	0.0833
p.S292N	DO222790	COCA	ICGC	PTTPVSS	DEG_SCF_FBW7_1	0.0556
p.P305L	DO233625	GACA	ICGC	PTTPVSS	DEG_SCF_FBW7_1	0.7582
p.P305L	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPVSS	DEG_SCF_FBW7_1	0.7582
p.Q297K	DO229032	LICA	ICGC	PTTPVSS	DEG_SCF_FBW7_1	0.1944
p.T303I	DO23874	LUAD	ICGC	PTTPVSS	DEG_SCF_FBW7_1	0.5966
p.T318A	DO222423	MELA	ICGC	PTTPVSS	DEG_SCF_FBW7_1	0.0556
p.T318A	DO37425	SKCM	ICGC	PTTPVSS	DEG_SCF_FBW7_1	0.0556
p.S308F	DO222615	MELA	ICGC	PTTPVSS	DEG_SCF_FBW7_1	0.7982
p.S308F	DO38177	SKCM	ICGC	PTTPVSS	DEG_SCF_FBW7_1	0.7982
p.A299T	NCI-SNU-1	stomach	COSMIC	PTTPVSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26367	Paired box protein Pax-6	DEG_SCF_FBW7_1	302:308	PTTPVSS	FBXW7	0.9531	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons