DegronMD

Uniprot ID: P14317

Source protein: Hematopoietic lineage cell-specific protein

Source gene: HCLS1

Class: DEG_SCF_FBW7_1

Location: 305:312

E3 ligase: FBXW7

DEGRON score: 0.9843

ASA_SCORE: 88.1625

COIL: 0.9648

CONS_SCORE: 0.3387

DSS_SCORE: 0.6573

HELIX: 0.0205

FCONS_SCORE: 0.9198

RIG_SCORE: 0.5285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R321M	TCGA-ER-A19P	SKCM	TCGA	PVGTPPSS	DEG_SCF_FBW7_1	0.0833
p.R321M	DO47623	SKCM	ICGC	PVGTPPSS	DEG_SCF_FBW7_1	0.0833
p.P309S	DO229177	LMS	ICGC	PVGTPPSS	DEG_SCF_FBW7_1	0.6752
p.V306A	SIDM00032	Bladder Carcinoma	GDSC	PVGTPPSS	DEG_SCF_FBW7_1	0.5825
p.L297F	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	PVGTPPSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14317	Hematopoietic lineage cell-specific protein	DEG_SCF_FBW7_1	305:312	PVGTPPSS	FBXW7	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons