DegronMD

Uniprot ID: P24723

Source protein: Protein kinase C eta type

Source gene: PRKCH

Class: DEG_SCF_FBW7_2

Location: 653:660

E3 ligase: FBXW7

DEGRON score: 0.9888

ASA_SCORE: 71.2375

COIL: 0.8876

CONS_SCORE: 0.5512

DSS_SCORE: 0.4878

HELIX: 0.0514

FCONS_SCORE: 0.9988

RIG_SCORE: 0.7576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E660D	TCGA-BR-4257	STAD	TCGA	PVLTPIDE	DEG_SCF_FBW7_2	0.6758
p.E660D	DO38683	STAD	ICGC	PVLTPIDE	DEG_SCF_FBW7_2	0.6758
p.H662L	DO228299	LICA	ICGC	PVLTPIDE	DEG_SCF_FBW7_2	0.2778
p.E670K	SIDM00120	Prostate Carcinoma	GDSC	PVLTPIDE	DEG_SCF_FBW7_2	0.0556
p.E670K	DU-145	prostate	COSMIC	PVLTPIDE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24723	Protein kinase C eta type	DEG_SCF_FBW7_2	653:660	PVLTPIDE	FBXW7	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons