DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PVSTPSKE
Uniprot ID:
Q6TDU7
Source protein:
Dynein axonemal intermediate chain 7
Source gene:
DNAI7
Class:
DEG_SCF_FBW7_2
Location:
265:272
E3 ligase:
FBXW7
DEGRON score:
0.8918
ASA_SCORE:
77.8875
COIL:
0.7955
CONS_SCORE:
0.2901
DSS_SCORE:
0.384
HELIX:
0.0786
FCONS_SCORE:
0.9234
RIG_SCORE:
0.6868
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DNAI7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PVSTPSKE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6TDU7
Dynein axonemal intermediate chain 7
DEG_SCF_FBW7_2
265:272
PVSTPSKE
FBXW7
0.8918
More...