DegronMD

Uniprot ID: Q7Z6J9

Source protein: tRNA-splicing endonuclease subunit Sen54

Source gene: TSEN54

Class: DEG_SCF_FBW7_1

Location: 404:410

E3 ligase: FBXW7

DEGRON score: 0.9695

ASA_SCORE: 43.9571

COIL: 0.8136

CONS_SCORE: 0.3861

DSS_SCORE: 0.4672

HELIX: 0.0129

FCONS_SCORE: 1.2001

RIG_SCORE: 0.7029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R396Q	TCGA-DX-AB32	SARC	TCGA	PVTPLLS	DEG_SCF_FBW7_1	0.1111
p.R396Q	DO220102	SARC	ICGC	PVTPLLS	DEG_SCF_FBW7_1	0.1111
p.V419M	DO233903	GACA	ICGC	PVTPLLS	DEG_SCF_FBW7_1	0.0833
p.G402C	DO228908	LICA	ICGC	PVTPLLS	DEG_SCF_FBW7_1	0.2778
p.R395L	DO229031	LICA	ICGC	PVTPLLS	DEG_SCF_FBW7_1	0.0833
p.T406P	DO219881	SKCA	ICGC	PVTPLLS	DEG_SCF_FBW7_1	0.7031
p.Q394R	ACH-000063	Non-Cancerous	CCLE	PVTPLLS	DEG_SCF_FBW7_1	0.0556
p.P417S	ACH-001568	Skin Cancer	CCLE	PVTPLLS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6J9	tRNA-splicing endonuclease subunit Sen54	DEG_SCF_FBW7_1	404:410	PVTPLLS	FBXW7	0.9695	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons