DegronMD

Uniprot ID: O43318

Source protein: Mitogen-activated protein kinase kinase kinase 7

Source gene: MAP3K7

Class: DEG_SCF_FBW7_1

Location: 480:486

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 88.4857

COIL: 0.948

CONS_SCORE: 0.3762

DSS_SCORE: 0.7231

HELIX: 0.0286

FCONS_SCORE: 1.0598

RIG_SCORE: 0.6257

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H479N	TCGA-25-2398	OV	TCGA	PWTPDDS	DEG_SCF_FBW7_1	0.3056
p.H479N	DO31250	OV	ICGC	PWTPDDS	DEG_SCF_FBW7_1	0.3056
p.S472P	TCGA-AP-A1DK	UCEC	TCGA	PWTPDDS	DEG_SCF_FBW7_1	0.5556
p.S472P	DO42033	UCEC	ICGC	PWTPDDS	DEG_SCF_FBW7_1	0.5556
p.S478R	TCGA-BR-6452	STAD	TCGA	PWTPDDS	DEG_SCF_FBW7_1	0.2778
p.S478R	DO38404	STAD	ICGC	PWTPDDS	DEG_SCF_FBW7_1	0.2778
p.T489A	TCGA-BR-8680	STAD	TCGA	PWTPDDS	DEG_SCF_FBW7_1	0.25
p.S492L	TCGA-DD-AACY	LIHC	TCGA	PWTPDDS	DEG_SCF_FBW7_1	0.1667
p.S492L	DO219567	LIHC	ICGC	PWTPDDS	DEG_SCF_FBW7_1	0.1667
p.P483H	TCGA-EE-A2GN	SKCM	TCGA	PWTPDDS	DEG_SCF_FBW7_1	0.7694
p.P483H	DO37896	SKCM	ICGC	PWTPDDS	DEG_SCF_FBW7_1	0.7694
p.P483T	TCGA-ER-A19P	SKCM	TCGA	PWTPDDS	DEG_SCF_FBW7_1	0.7031
p.P483T	DO47623	SKCM	ICGC	PWTPDDS	DEG_SCF_FBW7_1	0.7031
p.T471N	DO229027	LICA	ICGC	PWTPDDS	DEG_SCF_FBW7_1	0.5278
p.T476N	DO229041	LICA	ICGC	PWTPDDS	DEG_SCF_FBW7_1	0.2222
p.P470L	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	PWTPDDS	DEG_SCF_FBW7_1	0.0556
p.P470L	ACH-000544	Esophageal Cancer	CCLE	PWTPDDS	DEG_SCF_FBW7_1	0.0556
p.P470L	OE21	oesophagus	COSMIC	PWTPDDS	DEG_SCF_FBW7_1	0.0556
p.N490S	ACH-001649	Prostate Cancer	CCLE	PWTPDDS	DEG_SCF_FBW7_1	0.2222
p.T488I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PWTPDDS	DEG_SCF_FBW7_1	0.2778
p.T488I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PWTPDDS	DEG_SCF_FBW7_1	0.2778
p.P485S	SW684	soft_tissue	COSMIC	PWTPDDS	DEG_SCF_FBW7_1	0.6752

Drug responses associated with MAP3K7 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00145	ALL\|lymphoblastic_leukemia	p.R225C (No)	GDSC	NG-25	6.6446
SIDM00145	ALL\|lymphoblastic_leukemia	p.R225C (No)	GDSC	(5Z)-7-Oxozeaenol	0.7905
SIDM00959	LAML\|acute_myeloid_leukaemia	p.S328T (No)	GDSC	NG-25	0.9881
SIDM00959	LAML\|acute_myeloid_leukaemia	p.S328T (No)	GDSC	(5Z)-7-Oxozeaenol	1.7051
SIDM00849	KIRC\|kidney	p.R413C (No)	GDSC	NG-25	2.7539
SIDM00849	KIRC\|kidney	p.R413C (No)	GDSC	(5Z)-7-Oxozeaenol	2.5983
SIDM00272	BRCA\|breast	p.E260* (No)	GDSC	NG-25	10.9362
SIDM00272	BRCA\|breast	p.E260* (No)	GDSC	(5Z)-7-Oxozeaenol	6.294
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.G433* (No)	GDSC	NG-25	11.8275
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.G433* (No)	GDSC	(5Z)-7-Oxozeaenol	3.0603
SIDM01099	NB\|neuroblastoma	p.M131V (No)	GDSC	NG-25	34.2144
SIDM01099	NB\|neuroblastoma	p.M131V (No)	GDSC	(5Z)-7-Oxozeaenol	0.4028
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.Q80L (No)	GDSC	NG-25	4.5076
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.Q80L (No)	GDSC	(5Z)-7-Oxozeaenol	4.1898
SIDM00602	STAD\|stomach	p.G317C (No)	GDSC	NG-25	8.7692
SIDM00602	STAD\|stomach	p.G317C (No)	GDSC	(5Z)-7-Oxozeaenol	71.0421
SIDM00946	ALL\|T_cell_leukemia	p.T515I (No)	GDSC	NG-25	1.2783
SIDM00946	ALL\|T_cell_leukemia	p.T515I (No)	GDSC	(5Z)-7-Oxozeaenol	1.0401
SIDM00333	UCEC\|endometrium	p.C588Y (No)	GDSC	NG-25	13.4385
SIDM00333	UCEC\|endometrium	p.C588Y (No)	GDSC	(5Z)-7-Oxozeaenol	3.5224
SIDM00217	COREAD\|large_intestine	p.R413H (No)	GDSC	NG-25	10.2102
SIDM00217	COREAD\|large_intestine	p.R413H (No)	GDSC	(5Z)-7-Oxozeaenol	38.1046
SIDM00839	COREAD\|large_intestine	p.A400V (No)	GDSC	NG-25	19.5928
SIDM00839	COREAD\|large_intestine	p.A400V (No)	GDSC	(5Z)-7-Oxozeaenol	0.6232
SIDM00150	COREAD\|large_intestine	p.G191R (No)	GDSC	NG-25	24.3268
SIDM00150	COREAD\|large_intestine	p.G191R (No)	GDSC	(5Z)-7-Oxozeaenol	16.3343
SIDM00928	BRCA\|breast	p.T285I (No)	GDSC	NG-25	7.1494
SIDM00928	BRCA\|breast	p.T285I (No)	GDSC	(5Z)-7-Oxozeaenol	2.099
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.T515I (No)	GDSC	NG-25	0.6712
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.T515I (No)	GDSC	(5Z)-7-Oxozeaenol	1.1847
SIDM01013	CLL\|lymphoid_neoplasm_other	p.M392K (No)	GDSC	NG-25	6.0597
SIDM01013	CLL\|lymphoid_neoplasm_other	p.M392K (No)	GDSC	(5Z)-7-Oxozeaenol	1.1224
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P512S (No)	GDSC	NG-25	430.7165
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P512S (No)	GDSC	(5Z)-7-Oxozeaenol	9.278
SIDM00478	ESCA\|oesophagus	p.P470L (Yes)	GDSC	NG-25	64.87
SIDM00478	ESCA\|oesophagus	p.P470L (Yes)	GDSC	(5Z)-7-Oxozeaenol	4.0396
SIDM00594	LAML\|acute_myeloid_leukaemia	p.S328T (No)	GDSC	NG-25	5.0194
SIDM00594	LAML\|acute_myeloid_leukaemia	p.S328T (No)	GDSC	(5Z)-7-Oxozeaenol	2.5819

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PWTPDDS

Degron related mutations and impact score

Drug responses associated with MAP3K7 mutations

All proteins holding degron of PWTPDDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43318	Mitogen-activated protein kinase kinase kinase 7	DEG_SCF_FBW7_1	480:486	PWTPDDS	FBXW7	0.9963	More...