DegronMD

Uniprot ID: Q9Y4C8

Source protein: Probable RNA-binding protein 19

Source gene: RBM19

Class: DEG_SPOP_SBC_1

Location: 410:414

E3 ligase: SPOP

DEGRON score: 0.9068

ASA_SCORE: 59.2

COIL: 0.9396

CONS_SCORE: 0.4566

DSS_SCORE: 0.3113

HELIX: 0.0306

FCONS_SCORE: 0.9604

RIG_SCORE: 0.7544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L421F	TCGA-06-5416	GBM	TCGA	PYTST	DEG_SPOP_SBC_1	0.1389
p.L421F	DO10880	GBM	ICGC	PYTST	DEG_SPOP_SBC_1	0.1389
p.R407L	TCGA-17-Z045	LUAD	TCGA	PYTST	DEG_SPOP_SBC_1	0.25
p.R407L	TCGA-E2-A15O	BRCA	TCGA	PYTST	DEG_SPOP_SBC_1	0.25
p.R407L	DO2186	BRCA	ICGC	PYTST	DEG_SPOP_SBC_1	0.25
p.G402V	TCGA-55-7576	LUAD	TCGA	PYTST	DEG_SPOP_SBC_1	0.1111
p.G402V	DO24431	LUAD	ICGC	PYTST	DEG_SPOP_SBC_1	0.1111
p.E400K	TCGA-AZ-4315	COAD	TCGA	PYTST	DEG_SPOP_SBC_1	0.0556
p.E400K	DO8842	COAD	ICGC	PYTST	DEG_SPOP_SBC_1	0.0556
p.S413N	TCGA-EC-A24G	UCEC	TCGA	PYTST	DEG_SPOP_SBC_1	0.7069
p.S413N	DO40996	UCEC	ICGC	PYTST	DEG_SPOP_SBC_1	0.7069
p.D417Y	TCGA-RD-A8N1	STAD	TCGA	PYTST	DEG_SPOP_SBC_1	0.25
p.D417Y	DO50136	STAD	ICGC	PYTST	DEG_SPOP_SBC_1	0.25
p.L418M	DO228978	LICA	ICGC	PYTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4C8	Probable RNA-binding protein 19	DEG_SPOP_SBC_1	410:414	PYTST	SPOP	0.9068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons