DegronMD

Uniprot ID: Q6NXT6

Source protein: Transmembrane anterior posterior transformation protein 1 homolog

Source gene: TAPT1

Class: DEG_APCC_KENBOX_2

Location: 510:514

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9553

ASA_SCORE: 115.14

COIL: 0.8012

CONS_SCORE: 0.256

DSS_SCORE: 0.4447

HELIX: 0.1534

FCONS_SCORE: 0.9524

RIG_SCORE: 0.7814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I515M	TCGA-2W-A8YY	CESC	TCGA	QKENI	DEG_APCC_KENBOX_2	0.3056
p.I515M	DO223732	CESC	ICGC	QKENI	DEG_APCC_KENBOX_2	0.3056
p.I503N	TCGA-BW-A5NQ	LIHC	TCGA	QKENI	DEG_APCC_KENBOX_2	0.1389
p.I503N	DO49659	LIHC	ICGC	QKENI	DEG_APCC_KENBOX_2	0.1389
p.N522S	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	QKENI	DEG_APCC_KENBOX_2	0.1111
p.N522S	SIDM01021	Glioblastoma	GDSC	QKENI	DEG_APCC_KENBOX_2	0.1111
p.N522S	SIDM00892	Breast Carcinoma	GDSC	QKENI	DEG_APCC_KENBOX_2	0.1111
p.N522S	SIDM00312	Plasma Cell Myeloma	GDSC	QKENI	DEG_APCC_KENBOX_2	0.1111
p.N522S	SIDM00554	Ovarian Carcinoma	GDSC	QKENI	DEG_APCC_KENBOX_2	0.1111
p.N522S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	QKENI	DEG_APCC_KENBOX_2	0.1111
p.I503V	SIDM00845	Burkitt's Lymphoma	GDSC	QKENI	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NXT6	Transmembrane anterior posterior transformation protein 1 homolog	DEG_APCC_KENBOX_2	510:514	QKENI	APC,CDC20,FZR1	0.9553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons