DegronMD

Uniprot ID: Q16706

Source protein: Alpha-mannosidase 2

Source gene: MAN2A1

Class: DEG_APCC_TPR_1

Location: 1142:1144

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7424

ASA_SCORE: 81.8333

COIL: 0.3233

CONS_SCORE: 0.343

DSS_SCORE: 0.8218

HELIX: 0.001

FCONS_SCORE: 0.6763

RIG_SCORE: 0.8192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1144M	TCGA-44-3917	LUAD	TCGA	QLR	DEG_APCC_TPR_1	0.8632
p.R1144M	DO25242	LUAD	ICGC	QLR	DEG_APCC_TPR_1	0.8632
p.L1143M	SIDM00660	Colorectal Carcinoma	GDSC	QLR	DEG_APCC_TPR_1	0.5999
p.L1143M	ACH-000985	Colon/Colorectal Cancer	CCLE	QLR	DEG_APCC_TPR_1	0.5999
p.L1143M	LS-411N	large_intestine	COSMIC	QLR	DEG_APCC_TPR_1	0.5999
p.I1136V	SIDM00844	Burkitt's Lymphoma	GDSC	QLR	DEG_APCC_TPR_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16706	Alpha-mannosidase 2	DEG_APCC_TPR_1	1142:1144	QLR	APC,CDC20,FZR1	0.7424	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons