DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_SIAH_1

Location: 786:794

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9638

ASA_SCORE: 104.7333

COIL: 0.9529

CONS_SCORE: 0.4315

DSS_SCORE: 0.5003

HELIX: 0.0209

FCONS_SCORE: 0.9641

RIG_SCORE: 0.6608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V801M	TCGA-86-7701	LUAD	TCGA	QPLAQVPPQ	DEG_SIAH_1	0.1389
p.P784S	TCGA-EE-A29L	SKCM	TCGA	QPLAQVPPQ	DEG_SIAH_1	0.2778
p.P792S	TCGA-EE-A3JD	SKCM	TCGA	QPLAQVPPQ	DEG_SIAH_1	0.5641
p.P793L	TCGA-ET-A40P	THCA	TCGA	QPLAQVPPQ	DEG_SIAH_1	0.7582
p.P803S	TCGA-QC-A7B5	SARC	TCGA	QPLAQVPPQ	DEG_SIAH_1	0.0833
p.R780Q	DO48566	BLCA	ICGC	QPLAQVPPQ	DEG_SIAH_1	0.1667
p.S791Y	DO49795	BLCA	ICGC	QPLAQVPPQ	DEG_SIAH_1	0.712
p.R792L	DO25797	LUAD	ICGC	QPLAQVPPQ	DEG_SIAH_1	0.8428
p.R800Q	DO230961	LUSC	ICGC	QPLAQVPPQ	DEG_SIAH_1	0.1667
p.R800Q	DO224594	LUSC	ICGC	QPLAQVPPQ	DEG_SIAH_1	0.1667
p.R800W	DO43891	UCEC	ICGC	QPLAQVPPQ	DEG_SIAH_1	0.1667
p.L785Q	SIDM00806	Osteosarcoma	GDSC	QPLAQVPPQ	DEG_SIAH_1	0.3056
p.L785Q	ACH-000613	Bone Cancer	CCLE	QPLAQVPPQ	DEG_SIAH_1	0.3056
p.L785Q	ACH-001001	Bone Cancer	CCLE	QPLAQVPPQ	DEG_SIAH_1	0.3056
p.L785Q	ACH-001094	Myeloma	CCLE	QPLAQVPPQ	DEG_SIAH_1	0.3056
p.L785Q	HOS	bone	COSMIC	QPLAQVPPQ	DEG_SIAH_1	0.3056
p.Q779H	ACH-000602	Leukemia	CCLE	QPLAQVPPQ	DEG_SIAH_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SIAH_1	786:794	QPLAQVPPQ	SIAH1,SIAH2,SIAH3	0.9638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons