DegronMD

Uniprot ID: Q8TF40

Source protein: Folliculin-interacting protein 1

Source gene: FNIP1

Class: DEG_APCC_DBOX_1

Location: 905:913

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9703

ASA_SCORE: 82.0667

COIL: 0.6526

CONS_SCORE: 0.2657

DSS_SCORE: 0.4325

HELIX: 0.0968

FCONS_SCORE: 0.9951

RIG_SCORE: 0.7826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C896F	TCGA-53-A4EZ	LUAD	TCGA	QRDTLSILV	DEG_APCC_DBOX_1	0.0833
p.S895L	TCGA-98-8021	LUSC	TCGA	QRDTLSILV	DEG_APCC_DBOX_1	0.0556
p.L912F	TCGA-AJ-A3EL	UCEC	TCGA	QRDTLSILV	DEG_APCC_DBOX_1	0.6981
p.K897T	TCGA-DK-A6AW	BLCA	TCGA	QRDTLSILV	DEG_APCC_DBOX_1	0.2222
p.K923N	TCGA-EO-A22U	UCEC	TCGA	QRDTLSILV	DEG_APCC_DBOX_1	0.1667
p.E919D	TCGA-FI-A2D5	UCEC	TCGA	QRDTLSILV	DEG_APCC_DBOX_1	0.1667
p.A898V	DO8786	COAD	ICGC	QRDTLSILV	DEG_APCC_DBOX_1	0.1389
p.R907I	DO8264	COAD	ICGC	QRDTLSILV	DEG_APCC_DBOX_1	0.8102
p.N908I	DO234327	ESAD	ICGC	QRDTLSILV	DEG_APCC_DBOX_1	0.728
p.T923I	DO45223	LIRI	ICGC	QRDTLSILV	DEG_APCC_DBOX_1	0.1667
p.I897F	DO26458	LUSC	ICGC	QRDTLSILV	DEG_APCC_DBOX_1	0.2222
p.S913N	DO220876	MELA	ICGC	QRDTLSILV	DEG_APCC_DBOX_1	0.7069
p.I897N	DO50288	SKCM	ICGC	QRDTLSILV	DEG_APCC_DBOX_1	0.2222
p.K895N	DO43755	UCEC	ICGC	QRDTLSILV	DEG_APCC_DBOX_1	0.0556
p.D904E	SIDM00391	Plasma Cell Myeloma	GDSC	QRDTLSILV	DEG_APCC_DBOX_1	0.3056
p.P901H	SIDM00112	Kidney Carcinoma	GDSC	QRDTLSILV	DEG_APCC_DBOX_1	0.2222
p.P901H	U031	kidney	COSMIC	QRDTLSILV	DEG_APCC_DBOX_1	0.2222
p.D907N	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRDTLSILV	DEG_APCC_DBOX_1	0.5821
p.D907N	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	QRDTLSILV	DEG_APCC_DBOX_1	0.5821
p.M910I	ACH-001384	Thyroid Cancer	CCLE	QRDTLSILV	DEG_APCC_DBOX_1	0.7618
p.M910I	RO82-W-1	thyroid	COSMIC	QRDTLSILV	DEG_APCC_DBOX_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF40	Folliculin-interacting protein 1	DEG_APCC_DBOX_1	905:913	QRDTLSILV	APC,CDC20,FZR1	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons