DegronMD

Uniprot ID: Q9P2K8

Source protein: eIF-2-alpha kinase GCN2

Source gene: EIF2AK4

Class: DEG_APCC_DBOX_1

Location: 172:180

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5197

ASA_SCORE: 99.1556

COIL: 0.0272

CONS_SCORE: 0.2651

DSS_SCORE: 0.4488

HELIX: 0.9732

FCONS_SCORE: 1.0887

RIG_SCORE: 0.7365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H177L	DO45261	LIRI	ICGC	QREILHEIQ	DEG_APCC_DBOX_1	0.6202

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2K8	eIF-2-alpha kinase GCN2	DEG_APCC_DBOX_1	172:180	QREILHEIQ	APC,CDC20,FZR1	0.5197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons