DegronMD

Uniprot ID: Q9NR48

Source protein: Histone-lysine N-methyltransferase ASH1L

Source gene: ASH1L

Class: DEG_APCC_DBOX_1

Location: 2920:2928

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.543

ASA_SCORE: 64.1444

COIL: 0.0137

CONS_SCORE: 0.5459

DSS_SCORE: 0.4187

HELIX: 0.9868

FCONS_SCORE: 1.3557

RIG_SCORE: 0.807

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2924I	DO229032	LICA	ICGC	QRERLNQIL	DEG_APCC_DBOX_1	0.7174
p.N2925D	DO233205	GACA	ICGC	QRERLNQIL	DEG_APCC_DBOX_1	0.5821
p.R2912Q	TCGA-BS-A0UF	UCEC	TCGA	QRERLNQIL	DEG_APCC_DBOX_1	0.5556
p.R2912Q	DO41488	UCEC	ICGC	QRERLNQIL	DEG_APCC_DBOX_1	0.5556
p.K2929R	DO227834	COCA	ICGC	QRERLNQIL	DEG_APCC_DBOX_1	0.3056
p.P2931H	TCGA-CN-6010	HNSC	TCGA	QRERLNQIL	DEG_APCC_DBOX_1	0.25
p.P2931H	TCGA-EE-A20F	SKCM	TCGA	QRERLNQIL	DEG_APCC_DBOX_1	0.25
p.P2931H	DO14766	HNSC	ICGC	QRERLNQIL	DEG_APCC_DBOX_1	0.25
p.P2931H	DO37961	SKCM	ICGC	QRERLNQIL	DEG_APCC_DBOX_1	0.25
p.R2916Q	TCGA-W3-A828	SKCM	TCGA	QRERLNQIL	DEG_APCC_DBOX_1	0.2222
p.R2916Q	DO51273	SKCM	ICGC	QRERLNQIL	DEG_APCC_DBOX_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_APCC_DBOX_1	2920:2928	QRERLNQIL	APC,CDC20,FZR1	0.543	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons