DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
QRERLNQIL
Uniprot ID:
Q9NR48
Source protein:
Histone-lysine N-methyltransferase ASH1L
Source gene:
ASH1L
Class:
DEG_APCC_DBOX_1
Location:
2920:2928
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.543
ASA_SCORE:
64.1444
COIL:
0.0137
CONS_SCORE:
0.5459
DSS_SCORE:
0.4187
HELIX:
0.9868
FCONS_SCORE:
1.3557
RIG_SCORE:
0.807
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R2912Q
TCGA-BS-A0UF
UCEC
TCGA
QRERLNQIL
DEG_APCC_DBOX_1
0.5556
p.R2912Q
DO41488
UCEC
ICGC
QRERLNQIL
DEG_APCC_DBOX_1
0.5556
p.P2931H
TCGA-CN-6010
HNSC
TCGA
QRERLNQIL
DEG_APCC_DBOX_1
0.25
p.P2931H
TCGA-EE-A20F
SKCM
TCGA
QRERLNQIL
DEG_APCC_DBOX_1
0.25
p.P2931H
DO14766
HNSC
ICGC
QRERLNQIL
DEG_APCC_DBOX_1
0.25
p.P2931H
DO37961
SKCM
ICGC
QRERLNQIL
DEG_APCC_DBOX_1
0.25
p.R2916Q
TCGA-W3-A828
SKCM
TCGA
QRERLNQIL
DEG_APCC_DBOX_1
0.2222
p.R2916Q
DO51273
SKCM
ICGC
QRERLNQIL
DEG_APCC_DBOX_1
0.2222
p.K2929R
DO227834
COCA
ICGC
QRERLNQIL
DEG_APCC_DBOX_1
0.3056
p.N2925D
DO233205
GACA
ICGC
QRERLNQIL
DEG_APCC_DBOX_1
0.5821
p.L2924I
DO229032
LICA
ICGC
QRERLNQIL
DEG_APCC_DBOX_1
0.7174
Drug responses associated with ASH1L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRERLNQIL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NR48
Histone-lysine N-methyltransferase ASH1L
DEG_APCC_DBOX_1
2920:2928
QRERLNQIL
APC,CDC20,FZR1
0.543
More...