DegronMD

Uniprot ID: P26378

Source protein: ELAV-like protein 4

Source gene: ELAVL4

Class: DEG_APCC_DBOX_1

Location: 247:255

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8831

ASA_SCORE: 52.5333

COIL: 0.4269

CONS_SCORE: 0.2957

DSS_SCORE: 0.3343

HELIX: 0.4558

FCONS_SCORE: 0.76

RIG_SCORE: 0.8114

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R249C	TCGA-56-8624	LUSC	TCGA	QRFRLDNLL	DEG_APCC_DBOX_1	0.8301
p.R249L	TCGA-56-8624	LUSC	TCGA	QRFRLDNLL	DEG_APCC_DBOX_1	0.8428
p.R248Q	TCGA-AA-3955	COAD	TCGA	QRFRLDNLL	DEG_APCC_DBOX_1	0.7329
p.R248Q	TCGA-D3-A2JF	SKCM	TCGA	QRFRLDNLL	DEG_APCC_DBOX_1	0.7329
p.P246S	TCGA-EE-A3JD	SKCM	TCGA	QRFRLDNLL	DEG_APCC_DBOX_1	0.3056
p.H255Y	TCGA-FW-A3R5	SKCM	TCGA	QRFRLDNLL	DEG_APCC_DBOX_1	0.7229
p.L263M	TCGA-IB-7651	PAAD	TCGA	QRFRLDNLL	DEG_APCC_DBOX_1	0.1111
p.Q259H	TCGA-VS-A8EL	CESC	TCGA	QRFRLDNLL	DEG_APCC_DBOX_1	0.6667
p.Q247H	DO51624	CESC	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.647
p.M257I	DO16061	HNSC	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.2778
p.R250S	DO229008	LICA	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.6316
p.R237L	DO45500	LUSC	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.0556
p.R237C	DO45500	LUSC	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.0556
p.A258V	DO232842	NACA	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.25
p.A258V	DO232224	PBCA	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.25
p.L251M	DO46657	PAAD	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.711
p.V261I	DO228596	PRAD	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.1667
p.H243Y	DO37406	SKCM	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.2222
p.H243Y	SW684	soft_tissue	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.2222
p.S265F	DO51290	SKCM	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.0556
p.L255F	DO38380	STAD	ICGC	QRFRLDNLL	DEG_APCC_DBOX_1	0.587
p.K244T	SIDM02020	Esophageal Carcinoma	GDSC	QRFRLDNLL	DEG_APCC_DBOX_1	0.25
p.S250I	SIDM01090	Colorectal Carcinoma	GDSC	QRFRLDNLL	DEG_APCC_DBOX_1	0.7341
p.S250I	RKO	large_intestine	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.7341
p.S259F	SIDM00217	Colorectal Carcinoma	GDSC	QRFRLDNLL	DEG_APCC_DBOX_1	0.6667
p.S259F	SNU-1040	large_intestine	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.6667
p.H238R	ACH-000991	Colon/Colorectal Cancer	CCLE	QRFRLDNLL	DEG_APCC_DBOX_1	0.5278
p.H238R	SNU-81	large_intestine	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.5278
p.H238Y	ACH-002309	Sarcoma	CCLE	QRFRLDNLL	DEG_APCC_DBOX_1	0.5278
p.H238Y	SW684	soft_tissue	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.5278
p.H241Y	SW684	soft_tissue	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.1667
p.H243R	SNU-81	large_intestine	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.2222
p.H241R	SNU-81	large_intestine	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.1667
p.P239T	NCI-H661	lung	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.1111
p.P237T	NCI-H661	lung	COSMIC	QRFRLDNLL	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRFRLDNLL

Degron related mutations and impact score

Drug responses associated with ELAVL4 mutations

All proteins holding degron of QRFRLDNLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26378	ELAV-like protein 4	DEG_APCC_DBOX_1	247:255	QRFRLDNLL	APC,CDC20,FZR1	0.8831	More...