DegronMD

Uniprot ID: P26572

Source protein: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Source gene: MGAT1

Class: DEG_APCC_DBOX_1

Location: 68:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8421

ASA_SCORE: 80.1

COIL: 0.2127

CONS_SCORE: 0.3863

DSS_SCORE: 0.4485

HELIX: 0.7876

FCONS_SCORE: 1.3387

RIG_SCORE: 0.7572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A61T	TCGA-A5-A1OF	UCEC	TCGA	QRGLLQQIG	DEG_APCC_DBOX_1	0.1389
p.A61T	DO42568	UCEC	ICGC	QRGLLQQIG	DEG_APCC_DBOX_1	0.1389
p.R67W	TCGA-B5-A3FC	UCEC	TCGA	QRGLLQQIG	DEG_APCC_DBOX_1	0.3056
p.R67W	DO41871	UCEC	ICGC	QRGLLQQIG	DEG_APCC_DBOX_1	0.3056
p.E66D	DO232224	PBCA	ICGC	QRGLLQQIG	DEG_APCC_DBOX_1	0.2778
p.R85K	DO229227	THCA	ICGC	QRGLLQQIG	DEG_APCC_DBOX_1	0.0833
p.R67Q	DO229221	THCA	ICGC	QRGLLQQIG	DEG_APCC_DBOX_1	0.3056
p.R69C	DO42673	UCEC	ICGC	QRGLLQQIG	DEG_APCC_DBOX_1	0.8301
p.E62D	DO42673	UCEC	ICGC	QRGLLQQIG	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26572	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	DEG_APCC_DBOX_1	68:76	QRGLLQQIG	APC,CDC20,FZR1	0.8421	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons