DegronMD

Uniprot ID: Q9Y3R0

Source protein: Glutamate receptor-interacting protein 1

Source gene: GRIP1

Class: DEG_APCC_DBOX_1

Location: 842:850

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9363

ASA_SCORE: 86.8222

COIL: 0.868

CONS_SCORE: 0.3764

DSS_SCORE: 0.5906

HELIX: 0.0633

FCONS_SCORE: 1.0675

RIG_SCORE: 0.6634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E833K	TCGA-18-3409	LUSC	TCGA	QRGSLSPVT	DEG_APCC_DBOX_1	0.0833
p.E836D	TCGA-29-1771	OV	TCGA	QRGSLSPVT	DEG_APCC_DBOX_1	0.1667
p.E836D	TCGA-63-A5MT	LUSC	TCGA	QRGSLSPVT	DEG_APCC_DBOX_1	0.1667
p.E836D	DO28028	OV	ICGC	QRGSLSPVT	DEG_APCC_DBOX_1	0.1667
p.E847K	TCGA-3N-A9WC	SKCM	TCGA	QRGSLSPVT	DEG_APCC_DBOX_1	0.7022
p.E847K	DO51234	SKCM	ICGC	QRGSLSPVT	DEG_APCC_DBOX_1	0.7022
p.T848S	TCGA-A5-A0G1	UCEC	TCGA	QRGSLSPVT	DEG_APCC_DBOX_1	0.7116
p.L843M	TCGA-A5-A0G1	UCEC	TCGA	QRGSLSPVT	DEG_APCC_DBOX_1	0.711
p.S840F	TCGA-BR-4292	STAD	TCGA	QRGSLSPVT	DEG_APCC_DBOX_1	0.2778
p.S840F	DO38495	STAD	ICGC	QRGSLSPVT	DEG_APCC_DBOX_1	0.2778
p.R853Q	DO233168	GACA	ICGC	QRGSLSPVT	DEG_APCC_DBOX_1	0.25
p.R853Q	DO222390	MELA	ICGC	QRGSLSPVT	DEG_APCC_DBOX_1	0.25
p.F832L	DO228948	LICA	ICGC	QRGSLSPVT	DEG_APCC_DBOX_1	0.0556
p.G850R	DO218863	SKCA	ICGC	QRGSLSPVT	DEG_APCC_DBOX_1	0.7568
p.E847G	SIDM00652	Small Cell Lung Carcinoma	GDSC	QRGSLSPVT	DEG_APCC_DBOX_1	0.7199
p.E847G	ACH-000780	Lung Cancer	CCLE	QRGSLSPVT	DEG_APCC_DBOX_1	0.7199
p.E847G	NCI-H1105	lung	COSMIC	QRGSLSPVT	DEG_APCC_DBOX_1	0.7199
p.D845G	ACH-000978	Endometrial/Uterine Cancer	CCLE	QRGSLSPVT	DEG_APCC_DBOX_1	0.7198
p.D845G	EN	endometrium	COSMIC	QRGSLSPVT	DEG_APCC_DBOX_1	0.7198
p.N837K	ACH-001518	Endometrial/Uterine Cancer	CCLE	QRGSLSPVT	DEG_APCC_DBOX_1	0.1944
p.D836H	KYSE-410	oesophagus	COSMIC	QRGSLSPVT	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3R0	Glutamate receptor-interacting protein 1	DEG_APCC_DBOX_1	842:850	QRGSLSPVT	APC,CDC20,FZR1	0.9363	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons