DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
QRKALLHMF
Uniprot ID:
A8MWA6
Source protein:
Putative protein FAM90A22
Source gene:
FAM90A22
Class:
DEG_APCC_DBOX_1
Location:
113:121
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8412
ASA_SCORE:
101.7444
COIL:
0.6816
CONS_SCORE:
0.6036
DSS_SCORE:
0.8273
HELIX:
0.2562
FCONS_SCORE:
1.4081
RIG_SCORE:
0.6728
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A22 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRKALLHMF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8MWA6
Putative protein FAM90A22
DEG_APCC_DBOX_1
113:121
QRKALLHMF
APC,CDC20,FZR1
0.8412
More...