DegronMD

Uniprot ID: Q13263

Source protein: Transcription intermediary factor 1-beta

Source gene: TRIM28

Class: DEG_APCC_DBOX_1

Location: 252:260

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7129

ASA_SCORE: 49.9222

COIL: 0.015

CONS_SCORE: 0.5061

DSS_SCORE: 0.2681

HELIX: 0.9844

FCONS_SCORE: 1.0458

RIG_SCORE: 0.8236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R253H	TCGA-06-5416	GBM	TCGA	QRKLLASLV	DEG_APCC_DBOX_1	0.8244
p.R253H	DO10880	GBM	ICGC	QRKLLASLV	DEG_APCC_DBOX_1	0.8244
p.R262C	TCGA-B5-A3FC	UCEC	TCGA	QRKLLASLV	DEG_APCC_DBOX_1	0.2778
p.R262C	DO41871	UCEC	ICGC	QRKLLASLV	DEG_APCC_DBOX_1	0.2778
p.G264E	TCGA-QB-A6FS	SKCM	TCGA	QRKLLASLV	DEG_APCC_DBOX_1	0.2222
p.G264E	DO48654	SKCM	ICGC	QRKLLASLV	DEG_APCC_DBOX_1	0.2222
p.A267T	DO44079	BLCA	ICGC	QRKLLASLV	DEG_APCC_DBOX_1	0.1389
p.R262L	DO229037	LICA	ICGC	QRKLLASLV	DEG_APCC_DBOX_1	0.2778
p.L263F	DO229479	SKCA	ICGC	QRKLLASLV	DEG_APCC_DBOX_1	0.25
p.H262Y	DO38192	STAD	ICGC	QRKLLASLV	DEG_APCC_DBOX_1	0.2778
p.Q252L	SIDM00781	Colorectal Carcinoma	GDSC	QRKLLASLV	DEG_APCC_DBOX_1	0.6654
p.Q252L	ACH-001199	Colon/Colorectal Cancer	CCLE	QRKLLASLV	DEG_APCC_DBOX_1	0.6654
p.Q252L	SNU-C2B	large_intestine	COSMIC	QRKLLASLV	DEG_APCC_DBOX_1	0.6654
p.R262H	SIDM00217	Colorectal Carcinoma	GDSC	QRKLLASLV	DEG_APCC_DBOX_1	0.2778
p.R262H	ACH-000999	Colon/Colorectal Cancer	CCLE	QRKLLASLV	DEG_APCC_DBOX_1	0.2778
p.R262H	SNU-1040	large_intestine	COSMIC	QRKLLASLV	DEG_APCC_DBOX_1	0.2778
p.A248T	SIDM01609	Endometrial Carcinoma	GDSC	QRKLLASLV	DEG_APCC_DBOX_1	0.2222
p.A248T	ACH-000972	Endometrial/Uterine Cancer	CCLE	QRKLLASLV	DEG_APCC_DBOX_1	0.2222
p.L255F	SIDM01573	Plasma Cell Myeloma	GDSC	QRKLLASLV	DEG_APCC_DBOX_1	0.587
p.L255F	ACH-000576	Myeloma	CCLE	QRKLLASLV	DEG_APCC_DBOX_1	0.587
p.V249G	ACH-001699	Head and Neck Cancer	CCLE	QRKLLASLV	DEG_APCC_DBOX_1	0.25
p.V249A	ACH-002287	Colon/Colorectal Cancer	CCLE	QRKLLASLV	DEG_APCC_DBOX_1	0.25
p.V249A	NCI-H630	large_intestine	COSMIC	QRKLLASLV	DEG_APCC_DBOX_1	0.25
p.R248W	OE21	oesophagus	COSMIC	QRKLLASLV	DEG_APCC_DBOX_1	0.2222
p.R248W	SNU-1040	large_intestine	COSMIC	QRKLLASLV	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13263	Transcription intermediary factor 1-beta	DEG_APCC_DBOX_1	252:260	QRKLLASLV	APC,CDC20,FZR1	0.7129	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRKLLASLV

Degron related mutations and impact score

Drug responses associated with TRIM28 mutations

All proteins holding degron of QRKLLASLV