DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
QRKLLQWMG
Uniprot ID:
A6NE52
Source protein:
WD repeat-containing protein 97
Source gene:
WDR97
Class:
DEG_APCC_DBOX_1
Location:
1082:1090
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6244
ASA_SCORE:
76.8556
COIL:
0.2124
CONS_SCORE:
0.2975
DSS_SCORE:
0.6223
HELIX:
0.7828
FCONS_SCORE:
1.0599
RIG_SCORE:
0.753
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with WDR97 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRKLLQWMG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NE52
WD repeat-containing protein 97
DEG_APCC_DBOX_1
1082:1090
QRKLLQWMG
APC,CDC20,FZR1
0.6244
More...