DegronMD

Uniprot ID: Q5SVQ8

Source protein: Zinc finger and BTB domain-containing protein 41

Source gene: ZBTB41

Class: DEG_APCC_DBOX_1

Location: 60:68

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8819

ASA_SCORE: 79.3444

COIL: 0.6047

CONS_SCORE: 0.7305

DSS_SCORE: 0.4226

HELIX: 0.2737

FCONS_SCORE: 1.0874

RIG_SCORE: 0.7551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K71N	TCGA-AA-A010	COAD	TCGA	QRKLLSSLQ	DEG_APCC_DBOX_1	0.3611
p.K71N	TCGA-BK-A6W3	UCEC	TCGA	QRKLLSSLQ	DEG_APCC_DBOX_1	0.3611
p.K71N	DO50076	UCEC	ICGC	QRKLLSSLQ	DEG_APCC_DBOX_1	0.3611
p.R61K	TCGA-AP-A0LM	UCEC	TCGA	QRKLLSSLQ	DEG_APCC_DBOX_1	0.7237
p.R61K	DO43306	UCEC	ICGC	QRKLLSSLQ	DEG_APCC_DBOX_1	0.7237
p.R61G	TCGA-BP-4961	KIRC	TCGA	QRKLLSSLQ	DEG_APCC_DBOX_1	0.7568
p.R61G	DO17811	KIRC	ICGC	QRKLLSSLQ	DEG_APCC_DBOX_1	0.7568
p.P58A	TCGA-XF-AAMZ	BLCA	TCGA	QRKLLSSLQ	DEG_APCC_DBOX_1	0.2778
p.P58A	DO219051	BLCA	ICGC	QRKLLSSLQ	DEG_APCC_DBOX_1	0.2778
p.N70H	DO9876	COAD	ICGC	QRKLLSSLQ	DEG_APCC_DBOX_1	0.2778
p.K71T	DO222762	COCA	ICGC	QRKLLSSLQ	DEG_APCC_DBOX_1	0.3611
p.L74I	SIDM00832	Colorectal Carcinoma	GDSC	QRKLLSSLQ	DEG_APCC_DBOX_1	0.1667
p.L74I	ACH-000680	Colon/Colorectal Cancer	CCLE	QRKLLSSLQ	DEG_APCC_DBOX_1	0.1667
p.L74I	SW948	large_intestine	COSMIC	QRKLLSSLQ	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SVQ8	Zinc finger and BTB domain-containing protein 41	DEG_APCC_DBOX_1	60:68	QRKLLSSLQ	APC,CDC20,FZR1	0.8819	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons