DegronMD

Uniprot ID: P33992

Source protein: DNA replication licensing factor MCM5

Source gene: MCM5

Class: DEG_APCC_DBOX_1

Location: 726:734

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8638

ASA_SCORE: 97.5222

COIL: 0.3866

CONS_SCORE: 0.4073

DSS_SCORE: 0.5966

HELIX: 0.0139

FCONS_SCORE: 0.8841

RIG_SCORE: 0.8486

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R727H	TCGA-2W-A8YY	CESC	TCGA	QRKVLYRLK	DEG_APCC_DBOX_1	0.8244
p.R732H	TCGA-2W-A8YY	CESC	TCGA	QRKVLYRLK	DEG_APCC_DBOX_1	0.7133
p.R724C	TCGA-Q1-A6DV	CESC	TCGA	QRKVLYRLK	DEG_APCC_DBOX_1	0.2778
p.R717Q	ACH-000956	Prostate Cancer	CCLE	QRKVLYRLK	DEG_APCC_DBOX_1	0.0833
p.M725T	ACH-000967	Colon/Colorectal Cancer	CCLE	QRKVLYRLK	DEG_APCC_DBOX_1	0.3056
p.R718H	ACH-001786	Colon/Colorectal Cancer	CCLE	QRKVLYRLK	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33992	DNA replication licensing factor MCM5	DEG_APCC_DBOX_1	726:734	QRKVLYRLK	APC,CDC20,FZR1	0.8638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons