DegronMD

Uniprot ID: Q9HA47

Source protein: Uridine-cytidine kinase 1

Source gene: UCK1

Class: DEG_APCC_DBOX_1

Location: 21:29

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5668

ASA_SCORE: 26.3556

COIL: 0.3302

CONS_SCORE: 0.5733

DSS_SCORE: 0.6093

HELIX: 0.0048

FCONS_SCORE: 1.1018

RIG_SCORE: 0.7086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L37P	TCGA-B5-A0JN	UCEC	TCGA	QRPFLIGVS	DEG_APCC_DBOX_1	0.1111
p.L37P	DO41943	UCEC	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.1111
p.A33G	TCGA-XF-A9ST	BLCA	TCGA	QRPFLIGVS	DEG_APCC_DBOX_1	0.2222
p.A33G	DO223599	BLCA	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.2222
p.E29Q	DO229010	COCA	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.6744
p.E29Q	DO229013	COCA	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.6744
p.E29Q	DO229016	COCA	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.6744
p.E29Q	DO229003	COCA	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.6744
p.E29Q	DO229005	COCA	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.6744
p.Q21K	DO229026	LICA	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.5833
p.S37A	DO37798	SKCM	ICGC	QRPFLIGVS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HA47	Uridine-cytidine kinase 1	DEG_APCC_DBOX_1	21:29	QRPFLIGVS	APC,CDC20,FZR1	0.5668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons