DegronMD

Uniprot ID: Q9H9Q4

Source protein: Non-homologous end-joining factor 1

Source gene: NHEJ1

Class: DEG_APCC_DBOX_1

Location: 282:290

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9613

ASA_SCORE: 115.5333

COIL: 0.933

CONS_SCORE: 0.3503

DSS_SCORE: 0.7433

HELIX: 0.0382

FCONS_SCORE: 0.845

RIG_SCORE: 0.703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R295S	TCGA-A5-A1OF	UCEC	TCGA	QRPQLSKVK	DEG_APCC_DBOX_1	0.1944
p.R295S	DO42568	UCEC	ICGC	QRPQLSKVK	DEG_APCC_DBOX_1	0.1944
p.K293M	TCGA-BF-A5ES	SKCM	TCGA	QRPQLSKVK	DEG_APCC_DBOX_1	0.3611
p.K293M	DO219456	SKCM	ICGC	QRPQLSKVK	DEG_APCC_DBOX_1	0.3611
p.L286M	DO229029	LICA	ICGC	QRPQLSKVK	DEG_APCC_DBOX_1	0.711
p.L297I	DO229037	LICA	ICGC	QRPQLSKVK	DEG_APCC_DBOX_1	0.1389
p.L297F	DO220886	MELA	ICGC	QRPQLSKVK	DEG_APCC_DBOX_1	0.1389
p.S282N	DO38743	STAD	ICGC	QRPQLSKVK	DEG_APCC_DBOX_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9Q4	Non-homologous end-joining factor 1	DEG_APCC_DBOX_1	282:290	QRPQLSKVK	APC,CDC20,FZR1	0.9613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons