DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
QRRELEKLR
Uniprot ID:
A6NNM3
Source protein:
RIMS-binding protein 3B
Source gene:
RIMBP3B
Class:
DEG_APCC_DBOX_1
Location:
29:37
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5359
ASA_SCORE:
110.2667
COIL:
0.0238
CONS_SCORE:
0.3766
DSS_SCORE:
0.4148
HELIX:
0.9778
FCONS_SCORE:
1.0666
RIG_SCORE:
0.7884
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RIMBP3B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRRELEKLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NNM3
RIMS-binding protein 3B
DEG_APCC_DBOX_1
29:37
QRRELEKLR
APC,CDC20,FZR1
0.5359
More...